Ionizing Radiation-Induced 6-Thioguanine-Resistant Clones in Synchronous CHO Cells
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چکیده
منابع مشابه
Effects of quercetin on ionizing radiation-induced cellular responses in HepG2 cells
Background: Quercetin has been reported to modulate cell proliferation and apoptosis. The present study aimed at identifying whether treatment of ionizing radiation (IR) combined with quercetin induces apoptosis in HepG2 cells. Materials and Methods: HepG2 cells were plated at an appropriate density according to each experimental scale and irradiated with 1, 5 and 10 Gy gamma-rays from a 60Co s...
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The guanine analog, 6-thioguanine (4), has been found to be a potent inhibitor of animal neoplasms (2) and human leukemia (5) when administered alone, and even more potent when used in com bination with the inhibitor of de novo purine syn thesis, azaserine (10, 12). We have developed a thioguanine-resistant subline of the Ehrlich ascites carcinoma. Using this as a tool, we have studied the meta...
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A patient with acute myeloblastic leukaemia developed jaundice revealing peliosis hepatis after receiving 6-thioguanine for two months. Peliosis hepatis was severe and was associated with mild lesions of centrilobular veins. Withdrawal of 6-thioguanine was followed by a progressive improvement of liver dysfunction. This report shows that 6-thioguanine, a thiopurine already reported to be respon...
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ژورنال
عنوان ژورنال: Radiation Research
سال: 1980
ISSN: 0033-7587
DOI: 10.2307/3575363